Anti-Human TRIM22 Polyclonal Antibody (HC134014)

Name: Anti-Human TRIM22 Polyclonal Antibody
Brand: abinScience
SKU: HC134014
Price: 168 USD
Availability: InStock

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사양:

50ug
100ug

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개요
이미지
참고 문헌
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SDS

개요

카탈로그 번호

HC134014

설명

Anti-Human TRIM22 Polyclonal Antibody (HC134014) is a rabbit polyclonal antibody detecting TRIM22. Suitable for Human.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human TRIM22 (Ser317-Ser498).

타겟

50 kDa-stimulated trans-acting factor, E3 ubiquitin-protein ligase TRIM22, EC:2.3.2.27, RING finger protein 94, RING-type E3 ubiquitin transferase TRIM22, RNF94, STAF50, Staf-50, TRIM22, Tripartite motif-containing protein 22

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

Q8IYM9

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

E3 ubiquitin-protein ligase TRIM22 is a ~56 kDa protein. Interferon-induced E3 ubiquitin ligase that plays important roles in innate and adaptive immunity. Restricts the replication of many viruses including HIV-1, encephalomyocarditis virus (EMCV), hepatitis B virus (HBV), hepatitis C virus (HCV) or Zika virus (ZIKV). Mechanistically, negatively regulates HCV replication by promoting ubiquitination and subsequent degradation of viral NS5A. Also acts by promoting the degradation of Zika virus NS1 and NS3 proteins through proteasomal degradation. Acts as a suppressor of basal HIV-1 LTR-driven transcription by preventing Sp1 binding to the HIV-1 promoter.

1. Yang, C. et al. (2016) Cellular & molecular immunology 13, 94-102. PMID: 25683609

2. Inoue, A. et al. (2022) Biochimica et biophysica acta. Molecular cell research 1869, 119318. PMID: 35777501

3. Zu, S. et al. (2022) Cell & bioscience 12, 139. PMID: 36042495

4. Turrini, F. et al. (2015) Retrovirology 12, 104. PMID: 26683615

5. Fei, X. et al. (2022) Molecular therapy oncolytics 26, 413-428. PMID: 36159777

참고사항

For research use only

이미지

Western blot

Western blot analysis was performed using anti-TRIM22 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Hela cell lysate
Lane 2: K562 cell lysate
Lane 3: HL-60 cell lysate
Lane 4: Mouse thymus lysate
Lane 5: Mouse lung lysate

참고 문헌

데이터시트

Anti-Human TRIM22 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human TRIM22 Polyclonal Antibody (HC134014)

개요

이미지

참고 문헌

데이터시트

SDS