Anti-Human TRIM38 Polyclonal Antibody (HT014014)

Name: Anti-Human TRIM38 Polyclonal Antibody
Brand: abinScience
SKU: HT014014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HT014014

설명

Anti-Human TRIM38 Polyclonal Antibody (HT014014) is a rabbit polyclonal antibody detecting TRIM38 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human TRIM38 (Asp282-Asp465).

타겟

E3 ubiquitin-protein ligase TRIM38, 2.3.2.27, RING finger protein 15, Tripartite motif-containing protein 38, Zinc finger protein RoRet, TRIM38, RNF15, RORET

정제

Purified by antigen affinity column.

등록번호

O00635

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

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제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

E3 ubiquitin-protein ligase TRIM38 is a ~53 kDa protein. E3 ubiquitin-protein and E3 SUMO-protein ligase that acts as a regulator of innate immunity. Acts as a negative regulator of type I interferon IFN-beta production by catalyzing 'Lys-48'-linked polyubiquitination of AZI2/NAP1, leading to its degradation. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling. Acts as positive regulator of the cGAS-STING pathway by acting as a E3 SUMO-protein ligase: mediates sumoylation of CGAS and STING, preventing their degradation and thereby activating the innate immune response to DNA virus. Also acts as a negative regulator of NF-kappa-B signaling independently of its E3 protein ligase activity by promoting lysosome-dependent degradation of TAB2 and TAB3 adapters.

1. Xue, Q. et al. (2012) PloS one 7, e46825. PMID: 23056470

2. Hu, MM. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, 1509-14. PMID: 24434549

참고사항

For research use only.

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참고 문헌

데이터시트

Anti-Human TRIM38 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human TRIM38 Polyclonal Antibody (HT014014)

개요

이미지

참고 문헌

데이터시트

SDS