Anti-Human TRIM69 Polyclonal Antibody (HP348014)

Name: Anti-Human TRIM69 Polyclonal Antibody
Brand: abinScience
SKU: HP348014
Price: 168 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

가격(USD): --

사양:

50ug
100ug

수량:

문의하기

개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HP348014

설명

Anti-Human TRIM69 Polyclonal Antibody (HP348014) is a rabbit polyclonal antibody detecting TRIM69 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human TRIM69 (Thr331-Gln500).

타겟

Tripartite motif-containing protein 69, RFP-like domain-containing protein trimless, RNF36, E3 ubiquitin-protein ligase TRIM69, RING finger protein 36, RING-type E3 ubiquitin transferase TRIM69, TRIM69

정제

Purified by antigen affinity column.

등록번호

Q86WT6

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

E3 ubiquitin-protein ligase TRIM69 is a ~57 kDa protein. E3 ubiquitin ligase that plays an important role in antiviral immunity by restricting different viral infections including dengue virus or vesicular stomatitis indiana virus. Ubiquitinates viral proteins such as dengue virus NS3 thereby limiting infection. In addition, acts as a key mediator of type I interferon induced microtubule stabilization by directly associating to microtubules independently of its E3 ligase activity. Also plays a role in cataract formation together with TP53. Mechanistically, inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination.

1. Han, Y. et al. (2012) Biochemical and biophysical research communications 429, 6-11. PMID: 23131556

2. Wang, K. et al. (2018) PLoS pathogens 14, e1007287. PMID: 30142214

3. Rihn, SJ. et al. (2019) Journal of virology 93. PMID: 31375575

4. Kueck, T. et al. (2019) Journal of virology 93. PMID: 31578292

5. Rong, X. et al. (2019) Redox biology 22, 101157. PMID: 30844644

6. Song, Y. et al. (2022) Proceedings of the National Academy of Sciences of the United States of America 119, e2211467119. PMID: 36251989

7. Wang, Y. et al. (2023) Nucleic acids research 51, 10568-10589. PMID: 37739411

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human TRIM69 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human TRIM69 Polyclonal Antibody (HP348014)

개요

이미지

참고 문헌

데이터시트

SDS