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| 카탈로그 번호 | HF906013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | SAA1532 | ||||
| 타겟 | TRIO, Triple functional domain protein, PTPRF-interacting protein | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | O75962 | ||||
| RRID | Anti-Human TRIO Antibody (SAA1532) (abinScience Cat# HF906013, RRID:AB_3727293) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Triple functional domain protein (TRIO) is a ~346 kDa protein. Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases. Involved in coordinating actin remodeling, which is necessary for cell migration and growth. Plays a key role in the regulation of neurite outgrowth and lamellipodia formation. In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses. 1. Deinhardt, K. et al. (2011) Science signaling 4, ra82. PMID: 22155786 2. Pengelly, RJ. et al. (2016) Journal of medical genetics 53, 735-742. PMID: 27418539 3. Debant, A. et al. (1996) Proceedings of the National Academy of Sciences of the United States of America 93, 5466-71. PMID: 8643598 4. Seipel, K. et al. (1999) Journal of cell science 112 ( Pt 12), 1825-34. PMID: 10341202 5. Barbosa, S. et al. (2020) American journal of human genetics 106, 338-355. PMID: 32109419 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human TRIO Antibody (SAA1532)
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