Anti-Human TRPM2 Polyclonal Antibody (HA519014)

Name: Anti-Human TRPM2 Polyclonal Antibody
Brand: abinScience
SKU: HA519014
Price: 96 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HA519014

설명

Anti-Human TRPM2 Polyclonal Antibody (HA519014) is a rabbit polyclonal antibody detecting TRPM2 in ELISA, IHC, WB. Suitable for Rattus norvegicus, Mus musculus, and Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human TRPM2 (Lys140-Arg358).

타겟

TRPM2

정제

Purified by antigen affinity column.

등록번호

O94759

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

대체 이름

Transient receptor potential cation channel subfamily M member 2, Estrogen-responsive element-associated gene 1 protein, Long transient receptor potential channel 2, LTrpC-2, LTrpC2, Transient receptor potential channel 7, TrpC7, Transient receptor potential melastatin 2, TRPM2, EREG1, KNP3, LTRPC2, TRPC7

배경

Transient receptor potential cation channel subfamily M member 2 (TRPM2) is a ~171 kDa protein. Nonselective, voltage-independent cation channel that mediates Na(+) and Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels. Functions as a ligand-gated ion channel, gated by intracellular adenosine diphosphate ribose (ADP-ribose), Ca(2+), warm temperature, and oxidative stress. The precise physiological activators are under debate; the true, physiological activators may be ADP-ribose and ADP-ribose-2'-phosphate. Binding of ADP-ribose to the cytoplasmic Nudix domain causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening. Extracellular Ca(2+) passes through the channel and increases channel activity.

1. Perraud, AL. et al. (2001) Nature 411, 595-9. PMID: 11385575

2. Sano, Y. et al. (2001) Science (New York, N.Y.) 293, 1327-30. PMID: 11509734

3. Hara, Y. et al. (2002) Molecular cell 9, 163-73. PMID: 11804595

4. Zhang, W. et al. (2003) The Journal of biological chemistry 278, 16222-9. PMID: 12594222

5. Perraud, AL. et al. (2005) The Journal of biological chemistry 280, 6138-48. PMID: 15561722

6. Togashi, K. et al. (2006) The EMBO journal 25, 1804-15. PMID: 16601673

7. Csanády, L. et al. (2009) The Journal of general physiology 133, 189-203. PMID: 19171771

8. Yang, W. et al. (2010) The Journal of biological chemistry 285, 30411-8. PMID: 20660597

9. Kühn, FJ. et al. (2015) Scientific reports 5, 8032. PMID: 25620041

10. Li, F. et al. (2016) Journal of cell science 129, 2016-29. PMID: 27068538

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human TRPM2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human TRPM2 Polyclonal Antibody (HA519014)

개요

이미지

참고 문헌

데이터시트

SDS