

| 카탈로그 번호 | HF620014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human TSPAN15 Polyclonal Antibody (HF620014) is a rabbit polyclonal antibody detecting TSPAN15 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human TSPAN15 (Thr115-Ala235). | ||||||||
| 타겟 | Tetraspanin-15, Tspan-15, Tetraspan NET-7, Transmembrane 4 superfamily member 15, TSPAN15, NET7, TM4SF15, UNQ677/PRO1311 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O95858 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Tetraspanin-15 (TSPAN15) is a ~33 kDa protein. Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates. Promotes ADAM10-mediated cleavage of CDH2. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity. 1. Jouannet, S. et al. (2016) Cellular and molecular life sciences : CMLS 73, 1895-915. PMID: 26686862 2. Shah, J. et al. (2018) Cell reports 25, 2132-2147.e7. PMID: 30463011 3. Eschenbrenner, E. et al. (2020) Life science alliance 3. PMID: 31792032 4. Lipper, CH. et al. (2022) Structure (London, England : 1993) 30, 206-214.e4. PMID: 34739841 | ||||||||
| 참고사항 | For research use only. |
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