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| 카탈로그 번호 | HB737013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | SAA1592 | ||||
| 타겟 | TSPAN8, Tspan-8, Tumor-associated antigen CO-029, TM4SF3, Transmembrane 4 superfamily member 3, Tetraspanin-8 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | P19075 | ||||
| RRID | Anti-Human TSPAN8 Antibody (SAA1592) (abinScience Cat# HB737013, RRID:AB_3727353) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Tetraspanin-8 (TSPAN8) is a ~26 kDa protein. Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, migration and protein trafficking. Promotes ADAM17-mediated TNF processing through recruitment of ADAM17 to tetraspanin-enriched micro-domains (TEMs). Forms a complex with RICTOR and integrin alpha3/ITGA3 to mediate mTORC2 activation and AKT1 phosphorylation leading to cell migration. Reduces apoptosis and autophagy induced by high glucose levels through forming a complex with mTOR and RICTOR. 1. Schmidt, F. et al. (2016) Biological chemistry. PMID: 27180357 2. Müller, M. et al. (2022) Cells 11. PMID: 36078095 3. Pan, SJ. et al. (2015) International journal of molecular sciences 16, 5363-74. PMID: 25761241 4. Zhuang, L. et al. (2022) Cell biology international 46, 1693-1703. PMID: 35904232 5. Min, J. et al. (2023) Cellular and molecular life sciences : CMLS 80, 154. PMID: 37204469 6. Zhu, Y. et al. (2023) Cancers 15. PMID: 37835445 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human TSPAN8 Antibody (SAA1592)
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