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| 카탈로그 번호 | HP715014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human UBQLN4 Polyclonal Antibody (HP715014) is a rabbit polyclonal antibody detecting Ubiquilin-4; Ataxin-1 interacting ubiquitin-like protein; A1Up; Ataxin-1 ubiquitin-like-interacting protein A1U; Connexin43-interacting protein of 75 kDa; CIP75; UBQLN4; C1orf6; CIP75; UBIN. Suitable for Mouse and Human.
Highlights
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| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human UBQLN4 (Pro12-Lys83). | ||||||||
| 타겟 | Ubiquilin-4; Ataxin-1 interacting ubiquitin-like protein; A1Up; Ataxin-1 ubiquitin-like-interacting protein A1U; Connexin43-interacting protein of 75 kDa; CIP75; UBQLN4; C1orf6; CIP75; UBIN | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q9NRR5 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 배경 | Ubiquilin-4 (UBQLN4) is a ~63 kDa protein. Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins. Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain. Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 degradation by the proteasome. MRE11 degradation prevents homologous recombination repair, redirecting double-strand break repair toward non-homologous end joining (NHEJ). Specifically recognizes and binds mislocalized transmembrane-containing proteins and targets them to proteasomal degradation. 1. Riley, BE. et al. (2004) The Journal of biological chemistry 279, 42290-301. PMID: 15280365 2. Suzuki, R. et al. (2016) EMBO reports 17, 842-57. PMID: 27113755 3. Hirayama, S. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, E4199-E4208. PMID: 29666234 4. Jachimowicz, RD. et al. (2019) Cell 176, 505-519.e22. PMID: 30612738 5. Lee, DY. et al. (2013) EMBO reports 14, 373-81. PMID: 23459205 | ||||||||
| 참고사항 | For research use only |
Lane 1: Hela cell lysate
Lane 2: 293T cell lysate
Lane 3: MCF-7 cell lysate
Lane 4: K562 cell lysate
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