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| 카탈로그 번호 | HP057014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human USP20 (Ser781-Val914). | ||||||||
| 타겟 | LSFR3A, Ubiquitin carboxyl-terminal hydrolase 20, KIAA1003, Ubiquitin-specific-processing protease 20, VHL-interacting deubiquitinating enzyme 2, Ubiquitin thioesterase 20, VDU2, hVDU2, Deubiquitinating enzyme 20, USP20 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q9Y2K6 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Ubiquitin carboxyl-terminal hydrolase 20 (USP20) is a ~102 kDa protein. Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis. Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination. Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization. Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1. Acts as a positive regulator for NF-kappa-B activation by TNF through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability. 1. Zhang, M. et al. (2016) Cell research 26, 1302-1319. PMID: 27801882 2. Kim, JH. et al. (2018) EMBO reports 19. PMID: 29487085 3. Jean-Charles, PY. et al. (2016) The Journal of biological chemistry 291, 7450-64. PMID: 26839314 4. Ha, J. et al. (2020) International journal of molecular sciences 21. PMID: 32354117 5. Berthouze, M. et al. (2009) The EMBO journal 28, 1684-96. PMID: 19424180 6. Li, Z. et al. (2005) EMBO reports 6, 373-8. PMID: 15776016 7. Feng, J. et al. (2022) Biochemical and biophysical research communications 593, 122-128. PMID: 35063767 | ||||||||
| 참고사항 | For research use only. |
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