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| 카탈로그 번호 | HA920014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human USP30 Polyclonal Antibody (HA920014) is a rabbit polyclonal antibody detecting USP30 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human USP30 (Gly74-Lys355). | ||||||||
| 타겟 | Ubiquitin carboxyl-terminal hydrolase 30, 3.4.19.12, Deubiquitinating enzyme 30, Ubiquitin thioesterase 30, Ubiquitin-specific-processing protease 30, Ub-specific protease 30, USP30 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q70CQ3 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Ubiquitin carboxyl-terminal hydrolase 30 (USP30) is a ~58 kDa protein. Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy. Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling. Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65'. Acts as a negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2. 1. Nakamura, N. et al. (2008) Molecular biology of the cell 19, 1903-11. PMID: 18287522 2. Bingol, B. et al. (2014) Nature 510, 370-5. PMID: 24896179 3. Wauer, T. et al. (2015) The EMBO journal 34, 307-25. PMID: 25527291 4. Cunningham, CN. et al. (2015) Nature cell biology 17, 160-9. PMID: 25621951 | ||||||||
| 참고사항 | For research use only. |
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