Anti-Human USP5 Polyclonal Antibody (HC178014)

Name: Anti-Human USP5 Polyclonal Antibody
Brand: abinScience
SKU: HC178014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HC178014

설명

Anti-Human USP5 Polyclonal Antibody (HC178014) is a rabbit polyclonal antibody detecting USP5. Suitable for Mouse and Human.

Highlights

●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human USP5 (Lys163-Lys291).

타겟

Deubiquitinating enzyme 5, EC:3.4.19.12, ISOT, Isopeptidase T, USP5, Ubiquitin carboxyl-terminal hydrolase 5, Ubiquitin thioesterase 5, Ubiquitin-specific-processing protease 5

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

P45974

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

Ubiquitin carboxyl-terminal hydrolase 5 (USP5) is a ~95 kDa protein. Deubiquitinating enzyme that participates in a wide range of cellular processes by specifically cleaving isopeptide bonds between ubiquitin and substrate proteins or ubiquitin itself. Affects thereby important cellular signaling pathways such as NF-kappa-B, Wnt/beta-catenin, and cytokine production by regulating ubiquitin-dependent protein degradation. Participates in the activation of the Wnt signaling pathway by promoting FOXM1 deubiquitination and stabilization that induces the recruitment of beta-catenin to Wnt target gene promoter. Regulates the assembly and disassembly of heat-induced stress granules by mediating the hydrolysis of unanchored ubiquitin chains. Promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein.

1. Chen, Y. et al. (2016) The EMBO journal 35, 668-84. PMID: 26912724

2. Xie, X. et al. (2018) Journal of cell science 131. PMID: 29567855

3. Shi, S. et al. (2023) Hepatology communications 7. PMID: 37534934

4. Xiao, X. et al. (2023) Nature communications 14, 2859. PMID: 37208329

5. Pai, YL. et al. (2023) Cell death & disease 14, 540. PMID: 37607937

6. Qiao, Z. et al. (2025) PLoS pathogens 21, e1012843. PMID: 39761299

7. Mao, C. et al. (2024) The Journal of biological chemistry 300, 107592. PMID: 39032648

8. Shao, N. et al. (2025) Nature communications 16, 1313. PMID: 39900921

참고사항

For research use only

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참고 문헌

데이터시트

Anti-Human USP5 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human USP5 Polyclonal Antibody (HC178014)

개요

이미지

참고 문헌

데이터시트

SDS