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| 카탈로그 번호 | HC560053 |
|---|---|
| 종 반응성 | Human |
| 응용 분야 | FCM |
| 숙주 종 | Human |
| 클론성 | Monoclonal |
| 이소타입 | IgG1, kappa |
| 클론 ID | JP0514 |
| 타겟 | Synaptic vesicular amine transporter, Solute carrier family 18 member 2, Vesicular amine transporter 2, VAT2, Vesicular monoamine transporter 2, SLC18A2, SVMT, VMAT2 |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | Q05940 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 배경 | Synaptic vesicular amine transporter (VMAT2) is a ~55 kDa protein. Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports a variety of catecholamines such as dopamine, adrenaline and noradrenaline, histamine, and indolamines such as serotonin. Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates somatodendritic dopamine release in hippocampal neurons, likely as part of a regulated secretory pathway that integrates retrograde synaptic signals. 1. Rilstone, JJ. et al. (2013) The New England journal of medicine 368, 543-50. PMID: 23363473 2. Pidathala, S. et al. (2023) Nature 623, 1086-1092. PMID: 37914936 3. Wu, D. et al. (2024) Nature 626, 427-434. PMID: 38081299 4. Dalton, MP. et al. (2024) eLife 12. PMID: 38517752 5. Erickson, JD. et al. (1996) Proceedings of the National Academy of Sciences of the United States of America 93, 5166-71. PMID: 8643547 6. Erickson, JD. et al. (1995) Journal of molecular neuroscience : MN 6, 277-87. PMID: 8860238 |
| 참고사항 | For research use only |
HEK293T cells transiently transfected with human, mouse, rat, or pig VMAT1 or VMAT2 were stained with clone JP0514 at the indicated concentrations (0.01, 0.04, 0.16, 0.62, 2.5, and 10 µg/mL). The antibody specifically recognized human VMAT2, with no detectable binding to VMAT1 or to VMAT2 from other species.
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