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| 카탈로그 번호 | HD280014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human WDR81 Polyclonal Antibody (HD280014) is a rabbit polyclonal antibody detecting WDR81. Suitable for Human, Rat, and Mouse.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human WDR81 (Gly337-Gln614). | ||||||||
| 타겟 | WD repeat-containing protein 81, WDR81 | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q562E7 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 배경 | WD repeat-containing protein 81 (WDR81) is a ~211 kDa protein. Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C. 1. Liu, K. et al. (2016) The Journal of cell biology 212, 181-98. PMID: 26783301 2. Rapiteanu, R. et al. (2016) Traffic (Copenhagen, Denmark) 17, 940-58. PMID: 27126989 3. Liu, X. et al. (2017) The Journal of cell biology 216, 1301-1320. PMID: 28404643 | ||||||||
| 참고사항 | For research use only |
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