Anti-Human WRAP53 Polyclonal Antibody (HA912014)

Name: Anti-Human WRAP53 Polyclonal Antibody
Brand: abinScience
SKU: HA912014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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개요

카탈로그 번호

HA912014

설명

Anti-Human WRAP53 Polyclonal Antibody (HA912014) is a rabbit polyclonal antibody detecting WRAP53 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human WRAP53 (Ser165-Tyr418).

타겟

WD repeat-containing protein 79, TCAB1, WD40 repeat-containing protein antisense to TP53 gene, Telomerase Cajal body protein 1, WRAP53, WRAP53beta, WDR79

정제

Purified by antigen affinity column.

등록번호

Q9BUR4

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Telomerase Cajal body protein 1 (WRAP53) is a ~59 kDa protein. RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies. Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex. Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity.

1. Nguyen, THD. et al. (2018) Nature 557, 190-195. PMID: 29695869

2. Chen, L. et al. (2018) Cell 174, 218-230.e13. PMID: 29804836

3. Tycowski, KT. et al. (2009) Molecular cell 34, 47-57. PMID: 19285445

4. Egan, ED. et al. (2010) Molecular and cellular biology 30, 2775-86. PMID: 20351177

5. Venteicher, AS. et al. (2009) Science (New York, N.Y.) 323, 644-8. PMID: 19179534

6. Vogan, JM. et al. (2015) The Journal of biological chemistry 290, 21320-35. PMID: 26170453

참고사항

For research use only.

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참고 문헌

데이터시트

Anti-Human WRAP53 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human WRAP53 Polyclonal Antibody (HA912014)

개요

이미지

참고 문헌

데이터시트

SDS

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