Anti-Human WWC1 Polyclonal Antibody (HV200014)

Name: Anti-Human WWC1 Polyclonal Antibody
Brand: abinScience
SKU: HV200014
Price: 168 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

가격(USD): --

사양:

50ug
100ug

수량:

문의하기

개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HV200014

설명

Anti-Human WWC1 Polyclonal Antibody (HV200014) is a rabbit polyclonal antibody detecting WWC1. Suitable for Human and Mouse.

Highlights

●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human WWC1 (Arg661-Lys791).

타겟

HBeAg-binding protein 3, KIAA0869, KIBRA, Kidney and brain protein, Protein KIBRA, WW domain-containing protein 1, WWC1

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

Q8IX03

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

Protein KIBRA (WWC1) is a ~125 kDa protein. Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway. Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and function in the regulation of Hippo signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade.

1. Wennmann, DO. et al. (2014) Molecular biology and evolution 31, 1710-23. PMID: 24682284

2. Yu, J. et al. (2010) Developmental cell 18, 288-99. PMID: 20159598

3. Rayala, SK. et al. (2006) The Journal of biological chemistry 281, 19092-9. PMID: 16684779

4. Hilton, HN. et al. (2008) Biochimica et biophysica acta 1783, 383-93. PMID: 18190796

5. Duning, K. et al. (2008) Journal of the American Society of Nephrology : JASN 19, 1891-903. PMID: 18596123

6. Johannsen, S. et al. (2008) Neuroscience 155, 1165-73. PMID: 18672031

참고사항

For research use only

이미지

참고 문헌

데이터시트

Anti-Human WWC1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human WWC1 Polyclonal Antibody (HV200014)

개요

이미지

참고 문헌

데이터시트

SDS