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| 카탈로그 번호 | HB594014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human ZBED1 Polyclonal Antibody (HB594014) is a rabbit polyclonal antibody detecting E3 SUMO-protein ligase ZBED1; 2.3.2.-; DNA replication-related element-binding factor; Putative Ac-like transposable element; Zinc finger BED domain-containing protein 1; dREF homolog; ZBED1; ALTE; DREF; hDREF; KIAA0785; TRAMP in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant human ZBED1 (Asp119-Cys290). | ||||||||
| 타겟 | E3 SUMO-protein ligase ZBED1; 2.3.2.-; DNA replication-related element-binding factor; Putative Ac-like transposable element; Zinc finger BED domain-containing protein 1; dREF homolog; ZBED1; ALTE; DREF; hDREF; KIAA0785; TRAMP | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O96006 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | E3 SUMO-protein ligase ZBED1 is a ~78 kDa protein. Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase which sumoylates CHD3/Mi2-alpha, causing its release from DNA. This results in suppression of CHD3/Mi2-alpha transcription repression, increased recruitment of RNA polymerase II to gene promoters and positive regulation of transcription including H1-5 and ribosomal proteins such as: RPS6, RPL10A, and RPL12. The resulting increased transcriptional activity drives cell proliferation. Binds to 5'-TGTCG[CT]GA[CT]A-3' consensus sequences in gene promoters of ribosomal proteins. 1. Yamashita, D. et al. (2016) The Journal of biological chemistry 291, 11619-34. PMID: 27068747 2. Ohshima, N. et al. (2003) The Journal of biological chemistry 278, 22928-38. PMID: 12663651 3. Yamashita, D. et al. (2007) The Journal of biological chemistry 282, 7563-75. PMID: 17209048 4. Yamashita, D. et al. (2007) Molecular and cellular biology 27, 2003-13. PMID: 17220279 | ||||||||
| 참고사항 | For research use only |
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