中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HB820014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human ZFP36 (Thr106-Gly176). | ||||||||
| 타겟 | Zinc finger protein 36, RNF162A, TIS11A, Growth factor-inducible nuclear protein NUP475, Zfp-36, ZFP36, G0/G1 switch regulatory protein 24, G0S24, Tristetraprolin, NUP475, mRNA decay activator protein ZFP36, TTP | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P26651 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
||||||||
| 제품 사용 정보 |
| ||||||||
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | mRNA decay activator protein ZFP36 is a ~34 kDa protein. Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation. Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs. Self regulates by destabilizing its own mRNA. 1. Lai, WS. et al. (1999) Molecular and cellular biology 19, 4311-23. PMID: 10330172 2. Lai, WS. et al. (2000) The Journal of biological chemistry 275, 17827-37. PMID: 10751406 3. Lai, WS. et al. (2001) The Journal of biological chemistry 276, 23144-54. PMID: 11279239 4. Brooks, SA. et al. (2002) Arthritis and rheumatism 46, 1362-70. PMID: 12115244 5. Lai, WS. et al. (2003) Molecular and cellular biology 23, 3798-812. PMID: 12748283 6. Brooks, SA. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 172, 7263-71. PMID: 15187101 7. Ogilvie, RL. et al. (2005) Journal of immunology (Baltimore, Md. : 1950) 174, 953-61. PMID: 15634918 8. Marderosian, M. et al. (2006) Oncogene 25, 6277-90. PMID: 16702957 9. Lai, WS. et al. (2006) Molecular and cellular biology 26, 9196-208. PMID: 17030620 10. Kedar, VP. et al. (2010) PloS one 5, e9588. PMID: 20221403 | ||||||||
| 참고사항 | For research use only. |
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
