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| 카탈로그 번호 | HP941014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human ZFYVE27 (Lys361-Lys411). | ||||||||
| 타겟 | Spastic paraplegia 33 protein, SPG33, ZFYVE27, Protrudin, Zinc finger FYVE domain-containing protein 27 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q5T4F4 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Protrudin (ZFYVE27) is a ~45 kDa protein. Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity. Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections. 1. Shirane, M. et al. (2006) Science (New York, N.Y.) 314, 818-21. PMID: 17082457 2. Saita, S. et al. (2009) The Journal of biological chemistry 284, 13766-13777. PMID: 19289470 3. Hashimoto, Y. et al. (2014) The Journal of biological chemistry 289, 12946-61. PMID: 24668814 4. Chang, J. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 14954-9. PMID: 23969831 5. Matsuzaki, F. et al. (2011) Molecular biology of the cell 22, 4602-20. PMID: 21976701 | ||||||||
| 참고사항 | For research use only. |
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