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| 카탈로그 번호 | HY158014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-IFI30 Polyclonal Antibody (HY158014) is a rabbit polyclonal antibody detecting IFI30 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human IFI30 (Met1-Lys250). | ||||||||
| 타겟 | IP30, GILT, Gamma-interferon-inducible protein IP-30, IFI30, Legumaturain, Gamma-interferon-inducible lysosomal thiol reductase | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P13284 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Gamma-interferon-inducible lysosomal thiol reductase (IFI30) is a ~27 kDa protein. Lysosomal thiol reductase that catalyzes protein disulfide bonds reduction. Plays an important role in antigen processing and presentation, of namely both major histocompatibility complex (MHC) class I- and class II-restricted antigen by reducing the disulfide bonds of endocytosed proteins and facilitating their unfolding and optimal degradation. Shares with thioredoxin a reduction mechanism in which the N-terminal cysteine thiol group in the CXXC active site motif initiates a nucleophilic attack on the substrate disulfide bond,resulting in the formation of a mixed disulfide-linked enzyme-substrate intermediate (Probable). Subsequent intramolecular attack by the second cysteine thiol group enables the release of the reduced substrate and oxidized enzyme (Probable). Lysosomal cysteine is a physiological reducing agent that is capable of reducing IFI30, so that it can catalyzes the next reaction. 1. Arunachalam, B. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 745-50. PMID: 10639150 2. Phan, UT. et al. (2000) The Journal of biological chemistry 275, 25907-14. PMID: 10852914 | ||||||||
| 참고사항 | For research use only. |
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