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| 카탈로그 번호 | HA692014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-IMPA1 Polyclonal Antibody (HA692014) is a rabbit polyclonal antibody detecting Inositol monophosphatase 1; IMP 1; IMPase 1; 3.1.3.25; D-galactose 1-phosphate phosphatase; 3.1.3.94; Inositol-1(or 4)-monophosphatase 1; Lithium-sensitive myo-inositol monophosphatase A1; IMPA1; IMPA in ELISA, IHC, WB. Suitable for Human, Bovine, Mouse, and Pig.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant human IMPA1 (Met1-Asp277). | ||||||||
| 타겟 | Inositol monophosphatase 1; IMP 1; IMPase 1; 3.1.3.25; D-galactose 1-phosphate phosphatase; 3.1.3.94; Inositol-1(or 4)-monophosphatase 1; Lithium-sensitive myo-inositol monophosphatase A1; IMPA1; IMPA | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P29218, P20456, O55023, O77591 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Inositol monophosphatase 1 (IMPA1) is a ~30 kDa protein. Phosphatase involved in the dephosphorylation of myo-inositol monophosphates to generate myo-inositol. Is also able to dephosphorylate scyllo-inositol-phosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-1,3-diphosphate and scyllo-inositol-1,4-diphosphate. Also dephosphorylates in vitro other sugar-phosphates including D-galactose-1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate and 2'-AMP. Responsible for the provision of inositol required for synthesis of phosphatidylinositols and polyphosphoinositides, and involved in maintaining normal brain function. Has been implicated as the pharmacological target for lithium (Li(+)) action in brain, which is used to treat bipolar affective disorder. 1. Ohnishi, T. et al. (2007) The Journal of biological chemistry 282, 637-46. PMID: 17068342 2. Ganzhorn, AJ. et al. (1996) Biochemistry 35, 10957-66. PMID: 8718889 3. Parthasarathy, R. et al. (1997) Brain research 778, 99-106. PMID: 9462881 4. Figueiredo, T. et al. (2016) Molecular psychiatry 21, 1125-9. PMID: 26416544 | ||||||||
| 참고사항 | For research use only |
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