中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | VK013013 | ||||||
|---|---|---|---|---|---|---|---|
| 종 반응성 | Influenza A virus (H5N1), Influenza A virus (H1N1) | ||||||
| 응용 분야 | WB, ELISA | ||||||
| 숙주 종 | Mouse | ||||||
| 클론성 | Monoclonal | ||||||
| 이소타입 | IgG1 | ||||||
| 클론 ID | 2H6 | ||||||
| 타겟 | NS1 | ||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||
| 순도 | >90% as determined by SDS-PAGE. | ||||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||||
| 등록번호 | O56264 | ||||||
| 형태 | Liquid | ||||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
||||||
| 제품 사용 정보 |
| ||||||
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||
| 배경 | Non-structural protein 1 (NS1) is a ~26 kDa protein. Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1. In turn, unprocessed 3' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm. Cellular protein synthesis is thereby shut off very early after virus infection. Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism. Prevents the establishment of the cellular antiviral state by inhibiting TRIM25-mediated RIGI ubiquitination, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors IRF3 and IRF7. | ||||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-influenza A virus (H5N1) Non-structural protein 1 Antibody (2H6)
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
