中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HB061013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse, Rat | ||||
| 응용 분야 | IHC, WB | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | L24/18 | ||||
| 타겟 | Inositol-trisphosphate 3-kinase B, IP3 3-kinase B, Inositol 1, 4, 5-trisphosphate 3-kinase B, ITPKB, InsP 3-kinase B, IP3K B | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | Q14643,P11881,P29994 | ||||
| RRID | Anti-IP3 receptor, type 1 Antibody (L24/18) (abinScience Cat# HB061013, RRID:AB_3728178) |
||||
| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
||||
| 제품 사용 정보 |
| ||||
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 (ITPKB) is a ~313 kDa protein. Inositol 1,4,5-trisphosphate-gated calcium channel that, upon inositol 1,4,5-trisphosphate binding, mediates calcium release from the endoplasmic reticulum (ER). Undergoes conformational changes upon ligand binding, suggesting structural flexibility that allows the channel to switch from a closed state, capable of interacting with its ligands such as 1,4,5-trisphosphate and calcium, to an open state, capable of transferring calcium ions across the ER membrane. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CAMK2 complex. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix. 1. Adkins, CE. et al. (2000) The Biochemical journal 345 Pt 2, 357-63. PMID: 10620513 2. Gerber, S. et al. (2016) American journal of human genetics 98, 971-980. PMID: 27108797 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-IP3 receptor, type 1 Antibody (L24/18)
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
