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| 카탈로그 번호 | HB378014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-ITK Polyclonal Antibody (HB378014) is a rabbit polyclonal antibody detecting Tyrosine-protein kinase ITK/TSK; 2.7.10.2; Interleukin-2-inducible T-cell kinase; IL-2-inducible T-cell kinase; Kinase EMT; T-cell-specific kinase; Tyrosine-protein kinase Lyk; ITK; EMT; LYK in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant human ITK (Glu173-Leu620). | ||||||||
| 타겟 | Tyrosine-protein kinase ITK/TSK; 2.7.10.2; Interleukin-2-inducible T-cell kinase; IL-2-inducible T-cell kinase; Kinase EMT; T-cell-specific kinase; Tyrosine-protein kinase Lyk; ITK; EMT; LYK | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q08881, Q03526 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Tyrosine-protein kinase ITK/TSK is a ~71 kDa protein. Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. 1. Perez-Villar, JJ. et al. (2002) Biochemistry 41, 10732-40. PMID: 12186560 2. Grasis, JA. et al. (2003) Journal of immunology (Baltimore, Md. : 1950) 170, 3971-6. PMID: 12682224 3. Sela, M. et al. (2011) The EMBO journal 30, 3160-72. PMID: 21725281 | ||||||||
| 참고사항 | For research use only |
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