Anti-JAK1 Polyclonal Antibody (HB829014)

Name: Anti-JAK1 Polyclonal Antibody
Brand: abinScience
SKU: HB829014
Price: 96 USD
Availability: InStock

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개요
이미지
참고 문헌
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SDS

개요

카탈로그 번호

HB829014

설명

Anti-JAK1 Polyclonal Antibody (HB829014) is a rabbit polyclonal antibody detecting JAK1 in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human JAK1 (Pro32-Phe286).

타겟

JAK1B, JAK1, Janus kinase 1, Tyrosine-protein kinase JAK1, JAK1A, JAK-1

정제

Purified by antigen affinity column.

등록번호

P23458

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Tyrosine-protein kinase JAK1 is a ~133 kDa protein. Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Kinase partner for the type I interferon receptor IFNAR2. In response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins. Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors.

1. Staerk, J. et al. (2005) The Journal of biological chemistry 280, 41893-9. PMID: 16239216

2. Del Bel, KL. et al. (2017) The Journal of allergy and clinical immunology 139, 2016-2020.e5. PMID: 28111307

3. Gruber, CN. et al. (2020) Immunity 53, 672-684.e11. PMID: 32750333

4. Sakatsume, M. et al. (1995) The Journal of biological chemistry 270, 17528-34. PMID: 7615558

5. Müller, M. et al. (1993) Nature 366, 129-35. PMID: 8232552

6. Simoncic, PD. et al. (2002) Current biology : CB 12, 446-53. PMID: 11909529

7. Usacheva, A. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 169, 1302-8. PMID: 12133952

8. Novick, D. et al. (1995) Journal of leukocyte biology 57, 712-8. PMID: 7759950

참고사항

For research use only.

이미지

Western blot

Western blot analysis was performed using anti-JAK1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: PC-12 cell lysate

참고 문헌

데이터시트

Anti-JAK1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-JAK1 Polyclonal Antibody (HB829014)

개요

이미지

참고 문헌

데이터시트

SDS

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