Anti-JAK2 Polyclonal Antibody (HT091014)

Name: Anti-JAK2 Polyclonal Antibody
Brand: abinScience
SKU: HT091014
Price: 168 USD
Availability: InStock

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100ug

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HT091014

설명

Anti-JAK2 Polyclonal Antibody (HT091014) is a rabbit polyclonal antibody detecting JAK2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Chicken, and Pongo abelii.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human JAK2 (Asn508-Ala800).

타겟

Janus kinase 2, JAK2, Tyrosine-protein kinase JAK2, JAK-2

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

O60674

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Tyrosine-protein kinase JAK2 is a ~130 kDa protein. Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin receptor (MPL/TPOR); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor.

1. Greenhalgh, CJ. et al. (2005) The Journal of clinical investigation 115, 397-406. PMID: 15690087

2. Sakatsume, M. et al. (1995) The Journal of biological chemistry 270, 17528-34. PMID: 7615558

3. Oda, A. et al. (1998) Blood 92, 443-51. PMID: 9657743

4. Royer, Y. et al. (2005) The Journal of biological chemistry 280, 27251-61. PMID: 15899890

5. Saltzman, A. et al. (1998) Biochemical and biophysical research communications 246, 627-33. PMID: 9618263

6. Berry, DC. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 4340-5. PMID: 21368206

7. Guilluy, C. et al. (2010) Nature medicine 16, 183-90. PMID: 20098430

8. Jäkel, H. et al. (2011) Oncogene 30, 3502-12. PMID: 21423214

9. Dawson, MA. et al. (2009) Nature 461, 819-22. PMID: 19783980

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-JAK2 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-JAK2 Polyclonal Antibody (HT091014)

개요

이미지

참고 문헌

데이터시트

SDS

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