Anti-KMO Polyclonal Antibody (HT083014)

Name: Anti-KMO Polyclonal Antibody
Brand: abinScience
SKU: HT083014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HT083014

설명

Anti-KMO Polyclonal Antibody (HT083014) is a rabbit polyclonal antibody detecting KMO in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human KMO (Met1-Glu366).

타겟

KMO, Kynurenine 3-hydroxylase, Kynurenine 3-monooxygenase

정제

Purified by antigen affinity column.

등록번호

O15229

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Kynurenine 3-monooxygenase (KMO) is a ~55 kDa protein. Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable).

1. Amaral, M. et al. (2013) Nature 496, 382-5. PMID: 23575632

2. Mole, DJ. et al. (2016) Nature medicine 22, 202-9. PMID: 26752518

3. Hutchinson, JP. et al. (2017) Nature communications 8, 15827. PMID: 28604669

4. Gao, J. et al. (2018) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 32, 2036-2045. PMID: 29208702

5. Kim, HT. et al. (2018) Cell chemical biology 25, 426-438.e4. PMID: 29429898

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-KMO Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-KMO Polyclonal Antibody (HT083014)

개요

이미지

참고 문헌

데이터시트

SDS