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| 카탈로그 번호 | HB859013 | ||||
|---|---|---|---|---|---|
| 응용 분야 | IHC, WB | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | K14/16 | ||||
| 타겟 | Voltage-gated K(+) channel HuKIV, Voltage-gated potassium channel subunit Kv1.2, NGK1, KCNA2, Potassium voltage-gated channel subfamily A member 2, Voltage-gated potassium channel HBK5 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | P16389 | ||||
| RRID | Anti-Kv1.2 K+ channel Antibody (K14/16) (abinScience Cat# HB859013, RRID:AB_3728139) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Potassium voltage-gated channel subfamily A member 2 (KCNA2/Kv1.2 K+ channel) is a ~56 kDa protein. Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system. Prevents aberrant action potential firing and regulates neuronal output. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. 1. Imbrici, P. et al. (2000) Pflugers Archiv : European journal of physiology 441, 257-62. PMID: 11211111 2. Ramaswami, M. et al. (1990) Molecular and cellular neurosciences 1, 214-23. PMID: 19912772 3. Lee, JH. et al. (2013) Neuroscience letters 548, 143-8. PMID: 23769686 4. Po, S. et al. (1993) Circulation research 72, 1326-36. PMID: 8495559 5. Chen, P. et al. (2010) The Journal of biological chemistry 285, 14882-14889. PMID: 20220134 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Kv1.2 K+ channel Antibody (K14/16)
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