Anti-Kv2.2 K+ channel Recombinant Antibody (K37/89) (HA001013)

Anti-Kv2.2 K+ channel Antibody (K37/89) (abinScience Cat# HA001013, RRID:AB_3728626)
_x005F_x005F_x000D_ Copy Citation

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Potassium voltage-gated channel subfamily B member 2 (KCNB2/Kv2.2 K+ channel) is a ~102 kDa protein. Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes.