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| 카탈로그 번호 | HB384014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-LAMTOR4 Polyclonal Antibody (HB384014) is a rabbit polyclonal antibody detecting N-terminally processed; LAMTOR4; C7orf59 in ELISA, IHC, WB. Suitable for Human, Bovine, and Mouse.
Highlights
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| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant human LAMTOR4 (Met1-Val99). | ||||||||
| 타겟 | Ragulator complex protein LAMTOR4; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4; Ragulator complex protein LAMTOR4, N-terminally processed; LAMTOR4; C7orf59 | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q0VGL1, Q2M2U3, Q8CF66 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Ragulator complex protein LAMTOR4 is a ~10 kDa protein. As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. 1. Bar-Peled, L. et al. (2012) Cell 150, 1196-208. PMID: 22980980 2. de Araujo, MEG. et al. (2017) Science (New York, N.Y.) 358, 377-381. PMID: 28935770 3. Su, MY. et al. (2017) Molecular cell 68, 835-846.e3. PMID: 29107538 4. Yonehara, R. et al. (2017) Nature communications 8, 1625. PMID: 29158492 5. Shen, K. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, 9545-9550. PMID: 30181260 | ||||||||
| 참고사항 | For research use only |
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