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| 카탈로그 번호 | HB352014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-LCP2 Polyclonal Antibody (HB352014) is a rabbit polyclonal antibody detecting Lymphocyte cytosolic protein 2; SH2 domain-containing leukocyte protein of 76 kDa; SLP-76 tyrosine phosphoprotein; SLP76; LCP2 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant human LCP2 (Pro408-Pro533). | ||||||||
| 타겟 | Lymphocyte cytosolic protein 2; SH2 domain-containing leukocyte protein of 76 kDa; SLP-76 tyrosine phosphoprotein; SLP76; LCP2 | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q13094, Q60787 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Lymphocyte cytosolic protein 2 (LCP2) is a ~60 kDa protein. Adapter protein primarily involved in signaling pathways within T-cells, as well as other immune cells such as platelets, mast cells, and natural killer (NK) cells. Plays a crucial role for transducing signal from the T-cell receptor (TCR) after antigen recognition leading to T-cell activation. Mechanistically, once phosphorylated by the kinase ZAP70, mediates interactions with the guanine-nucleotide exchange factor VAV1, the adapter protein NCK and the kinase ITK. In turn, stimulates the activation of PKC-theta/PRKCQ and NF-kappa-B transcriptional activity in response to CD3 and CD28 costimulation. Also plays an essential role in AGER-induced signaling pathways including p38 MAPK and ERK1/2 activation leading to cytokine release and pro-inflammatory responses. 1. Herndon, TM. et al. (2001) Journal of immunology (Baltimore, Md. : 1950) 166, 5654-64. PMID: 11313406 2. Soini, L. et al. (2021) FEBS letters 595, 404-414. PMID: 33159816 3. Wu, J. et al. (1996) Immunity 4, 593-602. PMID: 8673706 4. Bubeck Wardenburg, J. et al. (1996) The Journal of biological chemistry 271, 19641-4. PMID: 8702662 5. Yan, Z. et al. (2021) Nature communications 12, 308. PMID: 33436632 | ||||||||
| 참고사항 | For research use only |
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