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| 카탈로그 번호 | HX858014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-LOXL3 Polyclonal Antibody (HX858014) is a rabbit polyclonal antibody detecting LOXL3 in ELISA, IHC, WB. Suitable for Human, Mouse, and Danio rerio.
Highlights
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| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human LOXL3 (Thr519-Asn726). | ||||||||
| 타겟 | Lysyl oxidase homolog 3, LOXL3, LOXL, Lysyl oxidase-like protein 3 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P58215 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Lysyl oxidase homolog 3 (LOXL3) is a ~83 kDa protein. Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins. Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin. Required for somite boundary formation by catalyzing oxidation of fibronectin (FN1), enhancing integrin signaling in myofibers and their adhesion to the myotendinous junction (MTJ). Acts as a regulator of inflammatory response by inhibiting differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acts by interacting with STAT3 in the nucleus and catalyzing both deacetylation and oxidation of lysine residues on STAT3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity. Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated. 1. Lee, JE. et al. (2006) The Journal of biological chemistry 281, 37282-90. PMID: 17018530 2. Ma, L. et al. (2017) Molecular cell 65, 296-309. PMID: 28065600 | ||||||||
| 참고사항 | For research use only. |
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