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| 카탈로그 번호 | VK765014 | ||||
|---|---|---|---|---|---|
| 설명 |
Anti-MACV Nucleoprotein Polyclonal Antibody (VK765014) is a rabbit polyclonal antibody detecting Nucleoprotein in ELISA, IHC, WB. Suitable for Machupo virus.
Highlights
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| 종 반응성 | Machupo virus (MACV), Junin mammarenavirus (JUNV) (Junn mammarenavirus) | ||||
| 응용 분야 | ELISA, IHC, WB | ||||
| 숙주 종 | Rabbit | ||||
| 클론성 | Polyclonal | ||||
| 이소타입 | IgG | ||||
| 면역원 | E. coli - derived recombinant MACV Nucleoprotein (Met1-Leu564). | ||||
| 타겟 | Nucleoprotein, 3.1.13.-, Nucleocapsid protein, Protein N, N | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 정제 | Purified by antigen affinity column. | ||||
| 등록번호 | P26578, P14239 | ||||
| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 배경 | Nucleoprotein is a ~63 kDa protein. Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of host IRF3, a protein involved in interferon activation pathway, leading to the inhibition of interferon-beta and IRF3-dependent promoters activation. | ||||
| 참고사항 | For research use only |
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