Anti-MANF Polyclonal Antibody (HX175014)

Name: Anti-MANF Polyclonal Antibody
Brand: abinScience
SKU: HX175014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HX175014

설명

Anti-MANF Polyclonal Antibody (HX175014) is a rabbit polyclonal antibody detecting MANF in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human MANF (Gly28-Leu182).

타겟

ARP, ARMET, MANF, Mesencephalic astrocyte-derived neurotrophic factor, Arginine-rich protein, Protein ARMET

정제

Purified by antigen affinity column.

등록번호

P55145

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a ~20 kDa protein. Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions.

1. Petrova, P. et al. (2003) Journal of molecular neuroscience : MN 20, 173-88. PMID: 12794311

2. Apostolou, A. et al. (2008) Experimental cell research 314, 2454-67. PMID: 18561914

3. Glembotski, CC. et al. (2012) The Journal of biological chemistry 287, 25893-904. PMID: 22637475

4. Bai, M. et al. (2018) Nature communications 9, 897. PMID: 29497057

5. Kovaleva, V. et al. (2023) Cell reports 42, 112066. PMID: 36739529

참고사항

For research use only.

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참고 문헌

데이터시트

Anti-MANF Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-MANF Polyclonal Antibody (HX175014)

개요

이미지

참고 문헌

데이터시트

SDS

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