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| 카탈로그 번호 | HX172014 | ||||||||
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| 설명 |
Anti-MAPK12 Polyclonal Antibody (HX172014) is a rabbit polyclonal antibody detecting MAPK12 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human MAPK12 (Tyr27-Phe311). | ||||||||
| 타겟 | Mitogen-activated protein kinase 12, ERK6, MAPK12, Extracellular signal-regulated kinase 6, ERK-6, MAP kinase p38 gamma, SAPK3, MAPK 12, Stress-activated protein kinase 3, MAP kinase 12, Mitogen-activated protein kinase p38 gamma | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P53778 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Mitogen-activated protein kinase 12 (MAPK12) is a ~41 kDa protein. Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. | ||||||||
| 참고사항 | For research use only. |
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