Anti-MAPK14 Polyclonal Antibody (HS804014)

Name: Anti-MAPK14 Polyclonal Antibody
Brand: abinScience
SKU: HS804014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HS804014

설명

Anti-MAPK14 Polyclonal Antibody (HS804014) is a rabbit polyclonal antibody detecting MAPK14 in ELISA, IHC, WB. Suitable for Dog, Cyprinus carpio, Danio rerio, Human, and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human MAPK14 (Met1-Ser360).

타겟

Stress-activated protein kinase 2a, Mitogen-activated protein kinase 14, Mitogen-activated protein kinase p38 alpha, SAPK2A, Cytokine suppressive anti-inflammatory drug-binding protein, CSBP, CSPB1, MAP kinase 14, MAP kinase MXI2, MAPK14, CSBP2, MAP kinase p38 alpha, MAPK 14, MXI2, CSAID-binding protein, MAX-interacting protein 2, CSBP1, SAPK2a

정제

Purified by antigen affinity column.

등록번호

Q16539

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Mitogen-activated protein kinase 14 (MAPK14) is a ~41 kDa protein. Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1.

1. Deak, M. et al. (1998) The EMBO journal 17, 4426-41. PMID: 9687510

2. Pierrat, B. et al. (1998) The Journal of biological chemistry 273, 29661-71. PMID: 9792677

3. Scheper, GC. et al. (2001) Molecular and cellular biology 21, 743-54. PMID: 11154262

4. Sayed, M. et al. (2000) The Journal of biological chemistry 275, 16569-73. PMID: 10747897

5. Khurana, A. et al. (2006) The Journal of biological chemistry 281, 35316-26. PMID: 17003045

6. Webber, JL. et al. (2010) The EMBO journal 29, 27-40. PMID: 19893488

7. Zwang, Y. et al. (2006) The EMBO journal 25, 4195-206. PMID: 16932740

8. Xu, P. et al. (2010) Molecular cell 37, 551-66. PMID: 20188673

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-MAPK14 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-MAPK14 Polyclonal Antibody (HS804014)

개요

이미지

참고 문헌

데이터시트

SDS

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