Anti-MAPRE1 Polyclonal Antibody (HS950014)

Name: Anti-MAPRE1 Polyclonal Antibody
Brand: abinScience
SKU: HS950014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HS950014

설명

Anti-MAPRE1 Polyclonal Antibody (HS950014) is a rabbit polyclonal antibody detecting MAPRE1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Coturnix coturnix.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human MAPRE1 (Ala2-Tyr268).

타겟

EB1, Microtubule-associated protein RP/EB family member 1, MAPRE1, APC-binding protein EB1, End-binding protein 1

정제

Purified by antigen affinity column.

등록번호

Q15691

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Microtubule-associated protein RP/EB family member 1 (MAPRE1) is a ~29 kDa protein. Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Recruits other +TIP proteins to microtubules by binding to a conserved Ser-X-Leu-Pro (SXLP) motif in their polypeptide chains. Promotes cytoplasmic microtubule nucleation and elongation. Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation. Assists chromosome alignment in metaphase by recruiting the SKA complex to the spindle and stabilizing its interactions with microtubule bundles (K-fibers).

1. Askham, JM. et al. (2002) Molecular biology of the cell 13, 3627-45. PMID: 12388762

2. Hayashi, I. et al. (2005) Molecular cell 19, 449-60. PMID: 16109370

3. Honnappa, S. et al. (2009) Cell 138, 366-76. PMID: 19632184

4. van der Vaart, B. et al. (2011) The Journal of cell biology 193, 1083-99. PMID: 21646404

5. Xia, P. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 16564-9. PMID: 23001180

6. Wei, J. et al. (2017) FEBS letters 591, 2379-2393. PMID: 28726242

7. Yang, C. et al. (2017) The Journal of cell biology 216, 3179-3198. PMID: 28814570

8. Song, X. et al. (2021) Nature chemical biology 17, 1314-1323. PMID: 34608293

9. Radhakrishnan, RM. et al. (2023) The Journal of biological chemistry 299, 102853. PMID: 36592928

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-MAPRE1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-MAPRE1 Polyclonal Antibody (HS950014)

개요

이미지

참고 문헌

데이터시트

SDS

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