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| 카탈로그 번호 | VK669014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Lake Victoria marburgvirus (MARV) (Marburg virus) | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant MARV GP1/Envelope glycoprotein 1 (Leu19-Gln205). | ||||||||
| 타겟 | Envelope glycoprotein, GP1, 2, GP, Virion spike glycoprotein, GP1, GP2, GP | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q1PDC7 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Envelope glycoprotein (GP1/Envelope glycoprotein 1) is a ~75 kDa protein. GP1 is responsible for binding to the receptor(s) on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into the host cell. Binding to CD209 and CLEC4M, which are respectively found on dendritic cells (DCs), and on endothelial cells of liver sinusoids and lymph node sinuses, facilitate infection of macrophages and endothelial cells. These interactions not only facilitate virus cell entry, but also allow capture of viral particles by DCs and subsequent transmission to susceptible cells without DCs infection (trans infection). | ||||||||
| 참고사항 | For research use only. |
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