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| 카탈로그 번호 | MD632014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Mouse ADGRV1 Polyclonal Antibody (MD632014) is a rabbit polyclonal antibody detecting ADGRV1. Suitable for Mouse.
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| 종 반응성 | Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Mouse ADGRV1 (Gly28-Asp386). | ||||||||
| 타겟 | ADGRV1, ADGRV1 subunit alpha, ADGRV1 subunit beta, Adgrv1, Adhesion G-protein coupled receptor V1, EC:3.4.-.-, G-protein coupled receptor 98, Gpr98, Kiaa0686, MASS1, Mass1, Monogenic audiogenic seizure susceptibility protein 1, Neurepin, Protein rueda, VLGR1, VLGR1 subunit beta, Vbeta, Very large G-protein coupled receptor 1, Vlgr1 | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q8VHN7 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 배경 | Adhesion G-protein coupled receptor V1 (ADGRV1) is a ~687 kDa protein. G-protein coupled receptor which has an essential role in the development of hearing and vision. Couples to G-alpha(i)-proteins, GNAI1/2/3, G-alpha(q)-proteins, GNAQ, as well as G-alpha(s)-proteins, GNAS, inhibiting adenylate cyclase (AC) activity and cAMP production. Required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells of the inner ear. In response to extracellular calcium, activates kinases PKA and PKC to regulate myelination by inhibiting the ubiquitination of MAG, thus enhancing the stability of this protein in myelin-forming cells of the auditory pathway. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. 1. McGee, J. et al. (2006) The Journal of neuroscience : the official journal of the Society for Neuroscience 26, 6543-53. PMID: 16775142 2. Michalski, N. et al. (2007) The Journal of neuroscience : the official journal of the Society for Neuroscience 27, 6478-88. PMID: 17567809 3. Yang, J. et al. (2010) PLoS genetics 6, e1000955. PMID: 20502675 4. Shin, D. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 19101-6. PMID: 24191038 5. Hu, QX. et al. (2014) The Journal of biological chemistry 289, 24215-25. PMID: 24962568 | ||||||||
| 참고사항 | For research use only |
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