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| 카탈로그 번호 | MT230014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Mouse AIM2 Polyclonal Antibody (MT230014) is a rabbit polyclonal antibody detecting Aim2 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| 종 반응성 | Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Mouse AIM2 (Glu153-Lys342). | ||||||||
| 타겟 | Interferon-inducible protein AIM2, Interferon-inducible protein 210, Ifi-210, Interferon-inducible protein p210, Aim2, Gm1313, Ifi210 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q91VJ1 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Interferon-inducible protein AIM2 is a ~40 kDa protein. Sensor component of the AIM2 inflammasome, which mediates inflammasome activation in response to the presence of double-stranded DNA (dsDNA) in the cytosol, leading to subsequent pyroptosis. Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation. Acts as a recognition receptor (PRR): specifically recognizes and binds dsDNA in the cytosol, and mediates the formation of the inflammasome polymeric complex composed of AIM2, CASP1 and PYCARD/ASC. Recruitment of pro-caspase-1 (proCASP1) to the AIM2 inflammasome promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), promoting cytokine secretion. In some cells, CASP1 activation mediates cleavage and activation of GSDMD, triggering pyroptosis without promoting cytokine secretion. 1. Roberts, TL. et al. (2009) Science (New York, N.Y.) 323, 1057-60. PMID: 19131592 2. Hornung, V. et al. (2009) Nature 458, 514-8. PMID: 19158675 3. Fernandes-Alnemri, T. et al. (2009) Nature 458, 509-13. PMID: 19158676 4. Bürckstümmer, T. et al. (2009) Nature immunology 10, 266-72. PMID: 19158679 5. Rathinam, VA. et al. (2010) Nature immunology 11, 395-402. PMID: 20351692 6. Fernandes-Alnemri, T. et al. (2010) Nature immunology 11, 385-93. PMID: 20351693 7. Sauer, JD. et al. (2010) Cell host & microbe 7, 412-9. PMID: 20417169 8. Jones, JW. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 9771-6. PMID: 20457908 9. Belhocine, K. et al. (2012) Cellular microbiology 14, 71-80. PMID: 21902795 10. Ru, H. et al. (2013) Cell research 23, 855-8. PMID: 23567559 | ||||||||
| 참고사항 | For research use only. |
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