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| 카탈로그 번호 | MF739013 |
|---|---|
| 종 반응성 | Mouse |
| 응용 분야 | Blocking, IHC |
| 숙주 종 | Mouse |
| 클론성 | Monoclonal |
| 이소타입 | IgG1, kappa |
| 클론 ID | HJ6.3 |
| 타겟 | Apo-E, Apolipoprotein E, APOE |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | P08226 |
| RRID | Anti-Mouse APOE Antibody (HJ6.3) (abinScience Cat# MF739013, RRID:AB_3725650) |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 배경 | Apolipoprotein E (APOE) is a ~35 kDa protein. APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL). It also binds a wide range of cellular receptors including the LDL receptor/LDLR and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles. 1. Gonzales, JC. et al. (2013) The Journal of clinical investigation 123, 2742-51. PMID: 23676495 |
| 참고사항 | For research use only. |
SEC-HPLC detection for Anti-Mouse APOE Antibody (HJ6.3).
SDS-PAGE for Anti-Mouse APOE Antibody (HJ6.3).
Western blot analysis was performed using anti-APOE monoclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse liver lysate
Lane 2: Mouse brain lysate
Lane 3: Mouse heart lysate
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