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| 카탈로그 번호 | MP220014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Mouse ASAH2 Polyclonal Antibody (MP220014) is a rabbit polyclonal antibody detecting ASAH2 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| 종 반응성 | Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Mouse ASAH2 (Glu641-Thr756). | ||||||||
| 타겟 | Neutral ceramidase (N-CDase) (NCDase) (EC 3.5.1.-) (EC 3.5.1.23) (Acylsphingosine deacylase 2) (N-acylsphingosine amidohydrolase 2) [Cleaved into: Neutral ceramidase soluble form] | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q9JHE3 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Neutral ceramidase (ASAH2) is a ~83 kDa protein. Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine. Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate from the degradation of sphingomyelin, a sphingolipid enriched in the plasma membrane of cells. Also participates in the hydrolysis of ceramides from the extracellular milieu allowing the production of sphingosine-1-phosphate inside and outside cells. 1. Tani, M. et al. (2000) The Journal of biological chemistry 275, 3462-8. PMID: 10652340 2. Tani, M. et al. (2000) The Journal of biological chemistry 275, 11229-34. PMID: 10753931 3. Kono, M. et al. (2006) The Journal of biological chemistry 281, 7324-31. PMID: 16380386 4. Choi, MS. et al. (2003) Gene 315, 113-22. PMID: 14557071 5. Novgorodov, SA. et al. (2011) The Journal of biological chemistry 286, 25352-62. PMID: 21613224 6. Tani, M. et al. (2005) The Journal of biological chemistry 280, 36592-600. PMID: 16126722 | ||||||||
| 참고사항 | For research use only. |
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