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| 카탈로그 번호 | MB991014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Mouse CASP1/Caspase-1 Polyclonal Antibody (MB991014) is a rabbit polyclonal antibody detecting Caspase-1 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| 종 반응성 | Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Mouse CASP1/Caspase-1 (Leu137-His402). | ||||||||
| 타겟 | Caspase-1, CASP-1, 3.4.22.36, Interleukin-1 beta convertase, IL-1BC, Interleukin-1 beta-converting enzyme, ICE, IL-1 beta-converting enzyme, p45, Caspase-1 subunit p20, Caspase-1 subunit p10, Casp1, Il1bc | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P29452 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Caspase-1 (CASP1) is a ~45 kDa protein. Thiol protease involved in a variety of inflammatory processes by proteolytically cleaving other proteins, such as the precursors of the inflammatory cytokines interleukin-1 beta (IL1B) and interleukin 18 (IL18) as well as the pyroptosis inducer Gasdermin-D (GSDMD), into active mature peptides. Plays a key role in cell immunity as an inflammatory response initiator: once activated through formation of an inflammasome complex, it initiates a pro-inflammatory response through the cleavage of the two inflammatory cytokines IL1B and IL18, releasing the mature cytokines which are involved in a variety of inflammatory processes. Cleaves a tetrapeptide after an Asp residue at position P1. Also initiates pyroptosis, a programmed lytic cell death pathway, through cleavage of GSDMD. In contrast to cleavage of interleukin IL1B, recognition and cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP1 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part. 1. Broz, P. et al. (2010) Cell host & microbe 8, 471-83. PMID: 21147462 2. Wang, K. et al. (2020) Cell 180, 941-955.e20. PMID: 32109412 3. Lamkanfi, M. et al. (2008) Molecular & cellular proteomics : MCP 7, 2350-63. PMID: 18667412 4. Erener, S. et al. (2012) Molecular cell 46, 200-11. PMID: 22464733 5. Nozaki, K. et al. (2022) Nature 606, 960-967. PMID: 35705808 6. Wang, Y. et al. (2017) Immunity 46, 393-404. PMID: 28314590 | ||||||||
| 참고사항 | For research use only. |
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