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| 카탈로그 번호 | MX131013 |
|---|---|
| 종 반응성 | Mouse |
| 응용 분야 | ELISA, Neutralization |
| 숙주 종 | Mouse |
| 클론성 | Monoclonal |
| 이소타입 | IgG2a, kappa |
| 클론 ID | SAA2679 |
| 타겟 | Beta-chemokine exodus-1, C-C motif chemokine 20, CC chemokine LARC, CC chemokine ST38, Ccl20, Larc, Liver and activation-regulated chemokine, MIP-3-alpha, Macrophage inflammatory protein 3 alpha, Scya20, Small-inducible cytokine A20 |
| 내독소 수준 | <10 EU/mg |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | O89093 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 배경 | C-C motif chemokine 20 (CCL20/MIP-3-alpha) is a ~10 kDa protein. Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and autoimmune diseases. CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Involved in the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. 1. Röhrl, J. et al. (2010) The Journal of biological chemistry 285, 7028-34. PMID: 20068036 2. Varona, R. et al. (1998) FEBS letters 440, 188-94. PMID: 9862452 3. Ito, T. et al. (2011) Experimental cell research 317, 613-9. PMID: 21376174 4. Yamazaki, T. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 181, 8391-401. PMID: 19050256 5. Bunting, MD. et al. (2014) Immunology and cell biology 92, 489-98. PMID: 24638065 6. Diao, R. et al. (2014) Science translational medicine 6, 249ra108. PMID: 25122636 7. Tanaka, Y. et al. (1999) European journal of immunology 29, 633-42. PMID: 10064080 |
| 참고사항 | For research use only |
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