Anti-Mouse NKG2A/CD159a Polyclonal Antibody (MB188014)

Name: Anti-Mouse NKG2A/CD159a Polyclonal Antibody
Brand: abinScience
SKU: MB188014
Price: 168 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

가격(USD):

사양:

50ug
100ug

수량:

문의하기

개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

MB188014

설명

Anti-Mouse NKG2A/CD159a Polyclonal Antibody (MB188014) is a rabbit polyclonal antibody detecting NKG2A/CD159a in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Mouse CD159a/KLRC1 (Glu131-Ile244).

타겟

Killer cell lectin-like receptor subfamily C, member 1, Natural killer cell protein group 2-A1, Natural killer cell receptor NKG2A, Klrc1, Nkg2a

정제

Purified by antigen affinity column.

등록번호

Q9Z202

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

NKG2-A/NKG2-B type II integral membrane protein (CD159a/KLRC1) is a ~26 kDa protein. Immune inhibitory receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule HLA-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self. Upon HLA-E-peptide binding, transmits intracellular signals through two immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHP-1 and INPPL1/SHP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules. Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions.

1. Sullivan, LC. et al. (2007) Immunity 27, 900-11. PMID: 18083576

2. Lin, Z. et al. (2023) Nature immunology 24, 1087-1097. PMID: 37264229

3. Valiante, NM. et al. (1997) Immunity 7, 739-51. PMID: 9430220

4. Braud, VM. et al. (1998) Nature 391, 795-9. PMID: 9486650

5. Kabat, J. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 169, 1948-58. PMID: 12165520

6. Le Dréan, E. et al. (1998) European journal of immunology 28, 264-76. PMID: 9485206

7. Kamiya, T. et al. (2019) The Journal of clinical investigation 129, 2094-2106. PMID: 30860984

8. Jabri, B. et al. (2002) Immunity 17, 487-99. PMID: 12387742

9. Bhagat, G. et al. (2008) The Journal of clinical investigation 118, 281-93. PMID: 18064301

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Mouse NKG2A/CD159a Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Mouse NKG2A/CD159a Polyclonal Antibody (MB188014)

개요

이미지

참고 문헌

데이터시트

SDS

빠른 접근

문의하기