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| 카탈로그 번호 | MV234014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Mouse CD169/SIGLEC1 Polyclonal Antibody (MV234014) is a rabbit polyclonal antibody detecting SIGLEC1. Suitable for Mouse.
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| 종 반응성 | Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Mouse CD169/SIGLEC1 (Gly22-Val235). | ||||||||
| 타겟 | CD169, SIGLEC1, SN, Sialic acid-binding Ig-like lectin 1, Sialoadhesin, Siglec-1 | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q62230 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 배경 | Sialoadhesin (CD169/SIGLEC1) is a ~182 kDa protein. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Plays a crucial role in limiting bacterial dissemination by engaging sialylated bacteria to promote effective phagocytosis and antigen presentation for the adaptive immune response. Mediates the uptake of various enveloped viruses via sialic acid recognition and subsequently induces the formation of intracellular compartments filled with virions (VCCs). In turn, enhances macrophage-to-T-cell transmission of several viruses including murine leukemia virus. Acts as an endocytic receptor mediating clathrin dependent endocytosis. 1. Chang, YC. et al. (2014) Journal of molecular medicine (Berlin, Germany) 92, 951-9. PMID: 24788876 2. Erikson, E. et al. (2015) The Journal of biological chemistry 290, 27345-27359. PMID: 26370074 | ||||||||
| 참고사항 | For research use only |
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