Anti-Mouse CCR8 Polyclonal Antibody (MW444014)

Name: Anti-Mouse CCR8 Polyclonal Antibody
Brand: abinScience
SKU: MW444014
Price: 168 USD
Availability: InStock

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개요

카탈로그 번호

MW444014

설명

Anti-Mouse CD198/CCR8 Polyclonal Antibody (MW444014) is a rabbit polyclonal antibody detecting C-C chemokine receptor type 8; C-C CKR-8; CC-CKR-8; CCR-8; CDw198; Ccr8; Cmkbr8; Ter1 in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant mouse CD198/CCR8 (Asp2-Met33&Asn92-Lys105&Tyr170-Ile200&His262-Leu278).

타겟

C-C chemokine receptor type 8; C-C CKR-8; CC-CKR-8; CCR-8; CDw198; Ccr8; Cmkbr8; Ter1

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

P56484

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

C-C chemokine receptor type 8 (CD198/CCR8) is a ~40 kDa protein. G protein-coupled receptor that can bind a variety of chemokines, such as CCL1, CCL8, CCL16, CCL18. Regulates monocyte and eosinophil chemotaxis. Undergoes internalization upon CCL18 binding, leading to induced migration and calcium flux of highly polarized Th2 cells. In microglial cells, promotes phagocytosis with CCL18 through NF-kappa-B and Src signaling pathways. Stimulation of the CCL1-CCR8 signaling axis protects the gut from acute intestinal damage by supporting lymphoid cells IFN-gamma production.

1. Goya, I. et al. (1998) Journal of immunology (Baltimore, Md. : 1950) 160, 1975-81. PMID: 9469461

2. Chensue, SW. et al. (2001) The Journal of experimental medicine 193, 573-84. PMID: 11238588

3. Kang, L. et al. (2020) Frontiers in immunology 11, 609400. PMID: 33613532

참고사항

For research use only

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