

| 카탈로그 번호 | MB811014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Mouse CD224/GGT1 Polyclonal Antibody (MB811014) is a rabbit polyclonal antibody detecting CD224 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| 종 반응성 | Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Mouse CD224/GGT1 (Arg39-Tyr568). | ||||||||
| 타겟 | Glutathione hydrolase 1 proenzyme, 3.4.19.13, Gamma-glutamyltransferase 1, Gamma-glutamyltranspeptidase 1, GGT 1, 2.3.2.2, Leukotriene-C4 hydrolase, 3.4.19.14, CD224, Glutathione hydrolase 1 heavy chain, Glutathione hydrolase 1 light chain, Ggt1, Ggt, Ggtp | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q60928 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Glutathione hydrolase 1 proenzyme (CD224/GGT1) is a ~61 kDa protein. Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates (such as maresin conjugate (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate, MCTR1) and other gamma-glutamyl compounds (such as leukotriene C4, LTC4). The metabolism of glutathione by GGT1 releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Contributes to cysteine homeostasis, glutathione homeostasis and in the conversion of the leukotriene LTC4 to LTD4. Indirectly regulates multiple aspects of skeletal biology. 1. Levasseur, R. et al. (2003) Endocrinology 144, 2761-4. PMID: 12810527 | ||||||||
| 참고사항 | For research use only. |
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