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| 카탈로그 번호 | MW637014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Mouse Leptin R Polyclonal Antibody (MW637014) is a rabbit polyclonal antibody detecting Leptin R in ELISA, IHC, WB. Suitable for Mouse, Rat.
Highlights
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| 종 반응성 | Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Mouse CD295/LEPR (Gly124-Asn429). | ||||||||
| 타겟 | Leptin receptor, OB receptor, Lepr | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 순도 | >95% as determined by SDS-PAGE. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P48356 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Leptin receptor (CD295/LEPR) is a ~130 kDa protein. Receptor for hormone LEP/leptin (Probable). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity. Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. 1. Hileman, SM. et al. (2002) Endocrinology 143, 775-83. PMID: 11861497 2. Banks, AS. et al. (2000) The Journal of biological chemistry 275, 14563-72. PMID: 10799542 3. Bahrenberg, G. et al. (2002) Molecular endocrinology (Baltimore, Md.) 16, 859-72. PMID: 11923481 4. Flak, JN. et al. (2014) Nature neuroscience 17, 1744-1750. PMID: 25383904 5. Ducy, P. et al. (2000) Cell 100, 197-207. PMID: 10660043 6. Bates, SH. et al. (2003) Nature 421, 856-9. PMID: 12594516 | ||||||||
| 참고사항 | For research use only. |
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