Anti-Mouse Dectin-1/CLEC7A Polyclonal Antibody (MV829014)

Name: Anti-Mouse Dectin-1/CLEC7A Polyclonal Antibody
Brand: abinScience
SKU: MV829014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

MV829014

설명

Anti-Mouse Dectin-1/CLEC7A Polyclonal Antibody (MV829014) is a rabbit polyclonal antibody detecting Dectin-1/CLEC7A in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Mouse CD369/CLEC7A (Asn122-Leu244).

타겟

C-type lectin domain family 7 member A (Beta-glucan receptor) (C-type lectin superfamily member 12) (Dendritic cell-associated C-type lectin 1) (DC-associated C-type lectin 1) (Dectin-1) (CD antigen CD369)

내독소 수준

Please contact with the lab for this information.

순도

>95% as determined by SDS-PAGE.

정제

Purified by antigen affinity column.

등록번호

Q6QLQ4

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

C-type lectin domain family 7 member A (CD369/CLEC7A) is a ~27 kDa protein. Lectin that functions as a pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia.

1. Brown, GD. et al. (2001) Nature 413, 36-7. PMID: 11544516

2. Adachi, Y. et al. (2004) Infection and immunity 72, 4159-71. PMID: 15213161

3. Taylor, PR. et al. (2007) Nature immunology 8, 31-8. PMID: 17159984

4. Gantner, BN. et al. (2003) The Journal of experimental medicine 197, 1107-17. PMID: 12719479

5. Viriyakosol, S. et al. (2005) Infection and immunity 73, 1553-60. PMID: 15731053

6. Yadav, M. et al. (2006) Blood 108, 3168-75. PMID: 16825490

7. Campuzano, A. et al. (2020) Journal of immunology (Baltimore, Md. : 1950) 204, 3296-3306. PMID: 32358020

8. Rogers, NC. et al. (2005) Immunity 22, 507-17. PMID: 15845454

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Mouse Dectin-1/CLEC7A Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Mouse Dectin-1/CLEC7A Polyclonal Antibody (MV829014)

개요

이미지

참고 문헌

데이터시트

SDS

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