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| 카탈로그 번호 | MW630107 |
|---|---|
| 브랜드 | abinScience |
| 종 반응성 | Mouse, Canine |
| 응용 분야 | FCM |
| 숙주 종 | Armenian Hamster |
| 클론성 | Monoclonal |
| 이소타입 | IgG |
| 클론 ID | 16-10A1 |
| 타겟 | CD80, BB1, T-lymphocyte activation antigen CD80, CD28LG, B7, CD28LG1, LAB7, Activation B7-1 antigen, CTLA-4 counter-receptor B7.1 |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | Q00609 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 배경 | T-lymphocyte activation antigen CD80 (B7-1) is a ~34 kDa protein. Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation. Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells by acting as a ligand for the CD28 receptor which is constitutively expressed on the cell surface of T-cells. In turn, activates different signaling pathways such as NF-kappa-B or MAPK leading to the production of different cytokines. Also acts as an inhibitor of T-cell activation by acting as a ligand for CTLA4, a decoy receptor, thereby blocking CD28-mediated T-cell priming. In addition, CD28/CD80 costimulatory signal stimulates glucose metabolism and ATP synthesis of T-cells by activating the PI3K/Akt signaling pathway. 1. Tseng, SY. et al. (2005) Journal of immunology (Baltimore, Md. : 1950) 175, 7829-36. PMID: 16339518 2. Freeman, GJ. et al. (1991) The Journal of experimental medicine 174, 625-31. PMID: 1714935 3. Good-Jacobson, KL. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 188, 4217-25. PMID: 22450810 |
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Mouse CD80/B7-1 Antibody (16-10A1)
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